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CDDO-Me

Overview
Catalog # bs-83121c-5-mg
Product Name CDDO-Me
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress.1 Inhibits the NF-κB pathway via inhibition of IKKα activation in vitro2 and reduces expression of proinflammatory cytokines in vivo3. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro.4 Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.5
Description CAS Number: 218600-53-4

Chemical Name: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester

Molecular weight: 505.7

Formula: C32H43NO4

Solubility: Soluble in DMSO (25 mg/ml with warming)

Physical Properties: White solid

Purity: >98% by HPLC NMR (Conforms)