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Locostatin

Overview
Catalog # bs-83112c-5-mg
Product Name Locostatin
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Description CAS Number: 133812-16-5

Chemical Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone

Molecular weight: 245.28

Formula: C14H15O3

Solubility: DMSO (60 mg/ml)

Physical Properties: Off-white solid

Purity: 98% by TLC NMR (Conforms)