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HET0016

Overview
Catalog # bs-83104c-5-mg
Product Name HET0016
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis.2 HET0016 attenuates cerebral ischemia-reperfusion injury3 as well as oxidative injury and peripheral nerve damage in type-2 diabetic mice4. It alleviates myocardial oxidative stress5 and restores endothelial function suggesting therapeutic potential in obesity-associated vascular disease6.
Description CAS Number: 339068-25-6

Chemical Name: N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine

Molecular weight: 206.29

Formula: C12H18N2O

Solubility: DMSO (20 mg/ml)

Physical Properties: Off-white solid

Purity: >98% by HPLC NMR (Conforms)