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IM-12

Overview
Catalog # bs-83094c-5-mg
Product Name IM-12
Specifications
Storage Buffer White or off-white solid
Storage Condition -20°C
Target
Product Information A potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt--catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4
Description CAS Number: 1129669-05-1

Chemical Name: 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Molecular weight: 377.41

Formula: C22H20FN3O2

Solubility: DMSO (50 mg/ml)

Physical Properties: Yellow solid

Purity: 98% by HPLC NMR (Conforms)