Fruquintinib

Overview
Catalog #	bs-83018c-5-mg
Product Name	Fruquintinib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Fruquintinib is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 It potently inhibited VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevented angiogenesis in vitro. Fruquintinib is currently is several clinical trials against metastatic colorectal cancer2 and nonsquamous non-small-cell lung cancer3.
Description	CAS Number: 1194506-26-7 Chemical Name: 6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide Molecular weight: 393.40 Formula: C21H19N3O4 Solubility: DMSO (5 mg/ml) Physical Properties: White soliod Purity: 98% by HPLC NMR (Conforms)