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CB-103

Overview
Catalog # bs-83004c-20-mg
Product Name CB-103
Specifications
Storage Buffer Pale yellow solid
Storage Condition RT
Target
Product Information Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.
Description CAS Number: 218457-67-1

Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine

Molecular weight: 242.32

Formula: C15H18N2O

Solubility: DMSO (>30 mg/ml)

Physical Properties: Off-white to pale orange solid

Purity: 98% by HPLC, NMR (Conforms)