Nitisinone
Overview | |
Catalog # | bs-82966c-50-mg |
Product Name | Nitisinone |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism. |
Description | CAS Number: 104206-65-7 Chemical Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione Molecular weight: 329.23 Formula: C14H10F3NO5 Solubility: DMSO (>10 mg/ml) Ethanol (10 mg/ml) Physical Properties: Beige solid Purity: >98% by TLC (NMR Conforms) |