Icilin
Overview | |
Catalog # | bs-82851c-10-mg |
Product Name | Icilin |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 µM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5 |
Description | CAS Number: 36945-98-9 Chemical Name: 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one Molecular weight: 311.29 Formula: C16H13N3O4 Solubility: DMSO (25 mg/ml) Physical Properties: Yellow solid Purity: >98% by TLC [5% methanol in methylene chloride; Rf = 0.40] |