Canagliflozin
Overview | |
Catalog # | bs-82692c-10-mg |
Product Name | Canagliflozin |
Specifications | |
Storage Buffer | Off-white solid |
Storage Condition | -20°C |
Target | |
Product Information | Potent inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), IC50 = 2.2 nM selective over SGLT1, IC50=910 nM.1 Dose dependently increases glucose excretion in healthy subjects.2 Displays beneficial effects in nonalcoholic fatty liver disease (NAFLD).3 Extends lifespan in male but not female mice.4 Inhibits cancer cell proliferation via inhibition of mitochondrial complex-1 supported respiration.5 Suppresses the growth of pancreatic cancer cells.6 |
Description | CAS Number: 842133-18-0 Chemical Name: (1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol Molecular weight: 444.52 Formula: C24H25FO5S Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms) |