Migalastat
Overview | |
Catalog # | bs-82542c-1-mg |
Product Name | Migalastat |
Specifications | |
Storage Buffer | Beige solid |
Storage Condition | -20°C |
Target | |
Product Information | Migalastat is a potent, selective, and orally available inhibitor of α-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded α-GalA shifting the folding behavior toward functional active conformation (pharmacological chaperone activity) followed by trafficking to the lysosomes.2 Migalastat is active broadly across species from Drosophila3 to human4. Clinically useful agent for Fabry disease.5 |
Description | CAS Number: 75172-81-5 Chemical Name: (2R,3S,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol HCl Molecular weight: 199.63 Formula: C6H13NO4 • HCl Solubility: DMSO (50 mg/ml) Physical Properties: White solid Purity: >98% by TLC, NMR (Conforms) |