ML297
Overview | |
Catalog # | bs-82264c-5-mg |
Product Name | ML297 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | Selective GIRK ½ (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2 Displays antiseizure activity2 and decreases anxiety-related behavior without sedative or addictive effects3. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells.4 Brain penetrant. |
Description | CAS Number: 1443246-62-5 Chemical Name: N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea Molecular weight: 328.32 Formula: C17H14F2N4O Solubility: DMSO (45 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |