ML-SA1
Overview | |
Catalog # | bs-82243c-10-mg |
Product Name | ML-SA1 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | RT |
Target | |
Product Information | TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4 |
Description | CAS Number: 332382-54-4 Chemical Name: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione Molecular weight: 362.43 Formula: C22H22N2O3 Solubility: DMSO (20 mg/ml) Ethanol (10 mg/ml) Physical Properties: Tan solid Purity: 98% by HPLC NMR (Conforms) |