ML239
Overview | |
Catalog # | bs-82231c-5-mg |
Product Name | ML239 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3 |
Description | CAS Number: 1378872-36-6 Chemical Name: (2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Molecular weight: 346.60 Formula: C13 H10 Cl3 N3 O2 Solubility: DMSO (25 mg/ml) DMF (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC, NMr (Conforms) |