iCRT5
Overview | |
Catalog # | bs-82207c-5-mg |
Product Name | iCRT5 |
Specifications | |
Storage Buffer | Yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | A selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable. |
Description | CAS Number: 18623-44-4 Chemical Name: 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid Molecular weight: 367.44 Formula: C16H17NO5S2 Solubility: DMSO (30 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms) |