Spautin-1
Overview | |
Catalog # | bs-82205c-5-mg |
Product Name | Spautin-1 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable. |
Description | CAS Number: 1262888-28-7 Chemical Name: 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine Molecular weight: 271.27 Formula: C15H11F2N3 Solubility: DMSO (50 mg/ml) Ethanol (15 mg/ml with warming) Physical Properties: Tan solid Purity: 98% by TLC, NMR (Conforms) |