iCRT5
Overview | |
Catalog # | bs-80217C |
Product Name | iCRT5 |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:367.44 Formula:C16H17NO5S2 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) Chemical Name:4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid |
Description | A selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable. |