Regorafenib [BAY 73-4506]
Overview | |
Catalog # | bs-75522c-5mg |
Product Name | Regorafenib [BAY 73-4506] |
Specifications | |
Storage Buffer | Solid |
Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
Target | |
Product Information | CAS Number: 755037-03-7 Molecular formula: C21H15ClF4N4O3 Molecular weight: 482.8 Purity: >98% (HPLC) Appearance: Light pink to white solid. Solubility: Soluble in DMSO (>50mg/ml). Slightly soluble in ethanol (1mg/ml). Insoluble in water. InChiKey: FNHKPVJBJVTLMP-UHFFFAOYSA-N SMILES: CNC(=O)C1=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=CC=N1 |
Description | Orally bioavailable potent antitumor, antiangiogenic, antiproliferative and antineoplastic agent. Multi-target kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRbeta, Kit, RET and Raf-1 with IC50 values of 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively. |