Boc-Asp(OMe)-FMK
Overview | |
Catalog # | bs-75313c-1mg |
Product Name | Boc-Asp(OMe)-FMK |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Stable for 3 years after receipt when stored at -20°C. |
Target | |
Product Information | CAS Number: 187389-53-3 Molecular formula: C11H18FNO5 Molecular weight: 263.3 Purity: >98% Appearance: White to off-white powder. Solubility: Soluble in ethanol (5mg/ml), DMSO or DMF (both 30mg/ml). InChiKey: IPYYWMLWOBWDDP-UHFFFAOYSA-N SMILES: FCC([C@@H](NC(OC(C)(C)C)=O)C(OC)=O)=O |
Description | Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha (IC50=39µM). Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective. |