(-)-Mitorubrinic acid

Overview
Catalog #	bs-75260c-1mg
Product Name	(-)-Mitorubrinic acid
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 58958-07-9 Molecular formula: C21H16O9 Molecular weight: 412.4 Purity: >90% (HPLC) Appearance: Yellow solid. Solubility: Soluble in DMSO, ethanol or methanol. InChiKey: ZJIWQCFXEQSFGR-YEFOHOTDSA-N SMILES: O=C1[C@@](C)(OC(C2=C(O)C=C(O)C=C2C)=O)C(C3=COC(/C=C/C(O)=O)=CC3=C1)=O
Description	Azaphilone fungal metabolite. Induces formation of chlamydospore-like cells in fungi. Trypsin inhibitor (IC50=16µg/ml). Mitorubrinic acid was shown to be a virulence factor of Penicillium marneffei by improving its intracellular survival in macrophages. P. marneffei is the most important thermal dimorphic fungus causing respiratory, skin and systemic mycosis in China and Southeast Asia. It is a common indicator disease of AIDS. Besides HIV positive patients, P. marneffei infections have been reported in other immunocompromised patients, such as transplant recipients, patients with systemic lupus erythematosus and on corticosteroid therapy.