(-)-Mitorubrinic acid
| Overview | |
| Catalog # | bs-75260C |
| Product Name | (-)-Mitorubrinic acid |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 58958-07-9 Molecular formula: C21H16O9 Molecular weight: 412.4 Purity: >90% (HPLC) Appearance: Yellow solid. Solubility: Soluble in DMSO, ethanol or methanol. InChiKey: ZJIWQCFXEQSFGR-YEFOHOTDSA-N SMILES: O=C1[C@@](C)(OC(C2=C(O)C=C(O)C=C2C)=O)C(C3=COC(/C=C/C(O)=O)=CC3=C1)=O |
| Description | Azaphilone fungal metabolite. Induces formation of chlamydospore-like cells in fungi. Trypsin inhibitor (IC50=16µg/ml). Mitorubrinic acid was shown to be a virulence factor of Penicillium marneffei by improving its intracellular survival in macrophages. P. marneffei is the most important thermal dimorphic fungus causing respiratory, skin and systemic mycosis in China and Southeast Asia. It is a common indicator disease of AIDS. Besides HIV positive patients, P. marneffei infections have been reported in other immunocompromised patients, such as transplant recipients, patients with systemic lupus erythematosus and on corticosteroid therapy. |
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