Mitoxantrone dihydrochloride
Overview | |
Catalog # | bs-6796c-10mg-solid |
Product Name | Mitoxantrone dihydrochloride |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 517.4 Formula: C22 H30 Cl2 N4 O6 CAS Number: 70476-82-3 InChi Key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N InChi: InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H Smiles: Cl.Cl.OC1=CC=C(O)C2=C1C(=O)C1C(=C(C=CC=1NCCNCCO)NCCNCCO)C2=O Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years |
Description | Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis. |