| Overview |
| bs-6588R-APC |
| ADAMTS10 Polyclonal Antibody, APC Conjugated |
| IF(IHC-P), IF(IHC-F), IF(ICC) |
| Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Rabbit |
| Specifications |
| APC |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ADAMTS10 |
| 851-950/1103 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 81794 |
| Secreted, Extracellular matrix |
| A disintegrin and metalloproteinase with thrombospondin mots 10; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 mot, 10; ADAM metallopeptidase with thrombospondin type 1 mot 10; ADAM TS10; EC 3.4.24; WMS; ATS10_HUMAN. |
| ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines. |
| Application Dilution |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
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