New to Bioss? Enjoy 35% of your first order. Use code "FirstOrder35" - Offer valid for new U.S. Customers on direct orders only

BLU-9931

Overview
Catalog # bs-6481c-10mg-solid
Product Name BLU-9931
Specifications
Storage Buffer Powder
Storage Condition Store in dry, dark place at -20C for 1 year.
Target
Product Information Molecular Weight: 509.38

Formula: C26 H22 Cl2 N4 O3

CAS Number: 1538604-68-0

InChi Key: TXEBNKKOLVBTFK-UHFFFAOYSA-N

InChi: InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)

Smiles: CC1=CC=CC(NC(=O)C=C)=C1NC1=NC2=CC=C(C=C2C=N1)C1C(Cl)=C(C=C(OC)C=1Cl)OC

Purity: 98.0

Solubility: Soluble in DMSO, not in water

Appearance: Solid Power

Shelf Life: 1.0 years
Description BLU-9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU-9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU-9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.