(Z)-4-Hydroxytamoxifen --- CRISPR Editing Enhancer
| Overview | |
| Catalog # | bs-60324c-2-mg-solid |
| Product Name | (Z)-4-Hydroxytamoxifen --- CRISPR Editing Enhancer |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Powder: 4C for 1 year, -20C for 3 years. DMSO: 4C for 3 month. |
| Target | |
| Product Information | Molecular Weight: 387.51 Formula: C26 H29 N O2 CAS Number: 68047-06-3 InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N InChi: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25- Smiles: CC/C(=C(\C1C=CC(O)=CC=1)/C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM; EtOH up to 50 mM Appearance: Solid powder Shelf Life: 1.0 years |
| Description | (Z)-4-Hydroxytamoxifen (also called 4-OH-TAM) was previously characterized as an Estrogen Receptor antagonist and now found to improve genome-editing specificity in CRISPR-mediated gene editing. It can activate intein-linked inactive Cas9, reducing off-target. Such system has ~25-fold higher specificity than wtCas9. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency than Tamoxifen. |
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