1, 4-DPCA --- Prolyl 4-hydroxylase (P4H) Inhibitor

Overview
Catalog #	bs-60288c-10mg-solid
Product Name	1, 4-DPCA --- Prolyl 4-hydroxylase (P4H) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 240.21 Formula: C13 H8 N2 O3 CAS Number: 331830-20-7 InChi Key: XZZHOJONZJQARN-UHFFFAOYSA-N InChi: InChI=1S/C13H8N2O3/c16-12-8-4-3-7-2-1-5-14-10(7)11(8)15-6-9(12)13(17)18/h1-6H,(H,15,16)(H,17,18) Smiles: OC(=O)C1=CNC2C(=CC=C3C=CC=NC3=2)C1=O Purity: 98.0 Solubility: DMSO up to 10 mM, EtOH up to 20 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	1, 4-DPCA is a selective and cell permeable prolyl 4-hydroxylase (P4H) inhibitor. It inhibits α-prolyl4-hydroxylase, an oxygen-sensing enzyme that targets the pro-angiogenic factor HIF-1α for destruction upon hydroxylation of a specific proline residue. It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis.