GNF-7, Ras Signaling Inhibitor
Overview | |
Catalog # | bs-60281c-2-mg-solid |
Product Name | GNF-7, Ras Signaling Inhibitor |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 547.53 Formula: C28 H24 F3 N7 O2 CAS Number: 839706-07-9 InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N InChi: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36) Smiles: CN1C2=NC(NC3=CC=C(C)N=C3)=NC=C2CN(C1=O)C1C=C(C=CC=1C)NC(=O)C1C=CC=C(C=1)C(F)(F)F Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years |
Description | GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. |