NSC697923 --- Ub-conjugating Enzyme (E2) Inhibitor

Overview
Catalog #	bs-60202c-2-mg-solid
Product Name	NSC697923 --- Ub-conjugating Enzyme (E2) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 267.26 Formula: C11 H9 N O5 S CAS Number: 343351-67-7 InChi Key: GAUHIPWCDXOLCZ-UHFFFAOYSA-N InChi: InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3 Smiles: CC1C=CC(=CC=1)S(=O)(=O)C1=CC=C(O1)[N+]([O-])=O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	NSC697923 is a cell permeable, potent and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. It selectively inhibits PMA-induced NF-κB activation, and also inhibits IκBα phosphorylation by both RANKL and LPS. It impedes the formation of the Ubc13 and ubiquitin thioester conjugate and suppresses constitutive NF-κB activity in ABC-DLBCL cells. It inhibits the proliferation and survival of ABC-DLBCL cells and GCB-DLBCL cells, suggesting the Ubc13-Uev1A may be crucial for DLBCL growth. In neuroblastoma (NB) cell lines, NSC697923 shows cytotoxic effect, and inhibits both anchorage-dependent and -independent colony formation. It also shows in vivo antitumor efficacy in NB orthotopic xenografts.