IDH2-C100, IHD2 Inhibitor

Overview
Catalog #	bs-60190c-2mg-solid
Product Name	IDH2-C100, IHD2 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 305.38 Formula: C18 H19 N5 CAS Number: 1446506-78-0 InChi Key: WVHMNCOFPWFUMF-UHFFFAOYSA-N InChi: InChI=1S/C18H19N5/c1-13(2)19-17-21-16(14-9-5-3-6-10-14)22-18(23-17)20-15-11-7-4-8-12-15/h3-13H,1-2H3,(H2,19,20,21,22,23) Smiles: CC(C)NC1N=C(NC2C=CC=CC=2)N=C(N=1)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	IDH2-C100 is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50 < 0.1 µM. It has IC50 < 0.1 µM in U87MG pLVX-IDH2 R140Q-neo cell based assay. It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis.