Remodelin --- Acetyl-transferase NAT10 Inhibitor

Overview
Catalog #	bs-60187c-2-mg-solid
Product Name	Remodelin --- Acetyl-transferase NAT10 Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 282.36 Formula: C15 H14 N4 S CAS Number: 949912-58-7 InChi Key: XAEJIFARBQJLML-UHFFFAOYSA-N InChi: InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19) Smiles: N#CC1=CC=C(C=C1)C1=CSC(NN=C2CCCC2)=N1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.