ML324 --- JMJD2 Histone Demethylase Inhibitor
Overview | |
Catalog # | bs-60183c-2mg-solid |
Product Name | ML324 --- JMJD2 Histone Demethylase Inhibitor |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Store in dry, dark place at -20C for 1 year. |
Target | |
Product Information | Molecular Weight: 349.43 Formula: C21 H23 N3 O2 CAS Number: 1222800-79-4 InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26) Smiles: CN(C)CCCNC(=O)C1C=CC(=CC=1)C1=CC(O)=C2N=CC=CC2=C1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
Description | ML324 is a potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0.92 µM toward JMJD2E. It has excellent in vitro ADME properties, and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice. |