PFI-2 --- SETD7 Histone Lysine Methyltransferase Inhibitor

Overview
Catalog #	bs-60182c-2-mg-solid
Product Name	PFI-2 --- SETD7 Histone Lysine Methyltransferase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 499.52 Formula: C23 H25 F4 N3 O3 S CAS Number: 1627676-59-8 InChi Key: JCKGSPAAPQRPBW-OAQYLSRUSA-N InChi: InChI=1S/C23H25F4N3O3S/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2/t21-/m1/s1 Smiles: O=C([C@@H](CC1C=CC=C(C=1)C(F)(F)F)NS(=O)(=O)C1=CC(F)=C2CNCCC2=C1)N1CCCC1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM. It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM), and biotinylated PFI-2 interacts with SETD7 in pull-down studies.