PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor

Overview
Catalog #	bs-60181c-5mg-solid
Product Name	PRMT1-2e, Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 401.26 Formula: C16 H14 Cl2 N2 O4 S CAS Number: 17328-16-4 InChi Key: SHRCVZJKZJGIHQ-UHFFFAOYSA-N InChi: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22) Smiles: O=S(=O)(C1C=CC(=CC=1)NC(=O)CCl)C1C=CC(=CC=1)NC(=O)CCl Purity: 98.0 Solubility: DMSO up to 50 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PRMT1-2e is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1.5 μM. It has no activity against CARM1 and Set7/9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1.97 μM) and LNCaP prostate cancer cells (IC50 ~4.49 μM). It can attenuate androgen-induced gene expression in LNCaP cells.