Overview |
bs-5258R-Biotin |
Cofilin (Tyr140) Polyclonal Antibody, Biotin Conjugated |
ELISA, IHC-P, IHC-F |
Human, Mouse, Rat |
Cow, Sheep, Pig |
Specifications |
Biotin |
Rabbit |
KLH conjugated synthetic phosphopeptide derived from human Cofilin around the phosphorylation site of Tyr140 |
Tyr140 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
1072 |
P23528 |
Cytoplasm, Nucleus, Cell membrane |
CFL; cofilin; HEL-S-15; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1 |
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. |
Application Dilution |
ELISA |
1:500-1000 |
IHC-P |
1:200-400 |
IHC-F |
1:100-500 |