phospho-LRP5 (Thr1492) Polyclonal Antibody, HRP Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-25114R-HRP |
Product Name | phospho-LRP5 (Thr1492) Polyclonal Antibody, HRP Conjugated |
Applications | ELISA, IHC-P |
Reactivity | Human |
Predicted Reactivity | Mouse, Rat, Dog, Cow, Pig |
Specifications | |
Conjugation | HRP |
Host | Rabbit |
Source | KLH conjugated Synthesised phosphopeptide derived from human LRP5 around the phosphorylation site of Thr1492 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1mg/ml |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 4041 |
Swiss Prot | O75197 |
Background | Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. |
Application Dilution | |
ELISA | 1:5000-10000 |
IHC-P | 1:100-500 |