Plexin A1 Polyclonal Antibody, Biotin Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-25079R-Biotin |
Product Name | Plexin A1 Polyclonal Antibody, Biotin Conjugated |
Applications | ELISA, IHC-P |
Reactivity | Rat |
Predicted Reactivity | Human, Mouse, Dog, Cow, Sheep, Horse, Pig |
Specifications | |
Conjugation | Biotin |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Plexin A1 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1mg/ml |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Gene ID | 5361 |
Swiss Prot | Q9UIW2 |
Synonyms | NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV; PLXA1_HUMAN. |
Background | Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury. |
Application Dilution | |
ELISA | 1:5000-10000 |
IHC-P | 1:100-500 |