Overview |
bs-10092R-HRP |
PLAG1 Polyclonal Antibody, HRP Conjugated |
WB, ELISA |
Mouse |
Human, Rat, Dog, Cow, Pig, Horse, Rabbit |
Specifications |
HRP |
Rabbit |
KLH conjugated synthetic peptide derived from human PLAG1 |
51-150/500 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
5324 |
Q6DJT9 |
Nucleus |
PSA; SGPA; ZNF912; Zinc finger protein PLAG1; Pleiomorphic adenoma gene 1 protein; PLAG1 |
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
Application Dilution |
WB |
1:300-5000 |
ELISA |
1:500-1000 |