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Calcitonin Gene Related Peptide (CGRP) Antibody

Applications

  • ICC

Reactivity

  • Human
  • Rat
Overview
Catalog # bsm-70037M
Product Name Calcitonin Gene Related Peptide (CGRP) Antibody
Applications ICC
Specificity Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut.
Reactivity Human, Rat
Specifications
Conjugation Unconjugated
Host Mouse
Source Purified rat alpha-CGRP.
Clonality Monoclonal
Clone # 4901
Isotype IgG2a
Concentration Lot Dependent
Purification Purified by Protein G.
Storage Buffer 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID 24241
Swiss Prot P01256
Synonyms Calcitonin/calcitonin related polypeptide alpha antibody, Alpha type CGRP antibody, Beta type CGRP antibody, CALC1 antibody, CALC2 antibody, CALCA antibody, CALCB antibody, Calcitonin 1 antibody, Calcitonin 2 antibody, Calcitonin gene related peptide I antibody, Calcitonin gene related peptide II antibody, Calcitonin related polypeptide alpha antibody, Calcitonin related polypeptide beta antibody, CGRP antibody, CGRP I antibody, CGRP II antibody, CGRP1 antibody, CGRP2 antibody, CT antibody, Katacalcin antibody, KC antibody
Background Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993).
Application Dilution
ICC 1:100-500