Overview |
bsm-54647R |
SAM68 Monoclonal Antibody |
WB, IHC-P, IF(ICC), IHC |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
Synthetic Peptide within C terminal human SAM68. |
Monoclonal |
4B4 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
10657 |
Q07666 |
Cytoplasm, Nucleus, Membrane |
FLJ34027 antibody, GAP associated tyrosine phosphoprotein p62 antibody, GAP-associated tyrosine phosphoprotein p62 antibody, KH domain containing RNA binding signal transduction associated 1 antibody, KH domain-containing antibody, KHDR1_HUMAN antibody, Khdrbs1 antibody, p21 Ras GTPase activating protein associated p62 antibody, p21 Ras GTPase-activating protein-associated p62 antibody, p62 antibody, p68 antibody, RNA-binding antibody, Sam68 antibody, signal transduction-associated protein 1 antibody, Src associated in mitosis 68 kDa protein antibody, Src-associated in mitosis 68 kDa protein antibody |
Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IF(ICC) |
1:50-200 |
IHC |
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