Overview |
bsm-54250R |
SF3B1 (6C6) Monoclonal Antibody |
WB, IHC-P |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein within human SF3B1 aa 1-150 |
Monoclonal |
6C6 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Target |
3451 |
O75533 |
Nucleus |
Splicing factor 3B subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; Spliceosome-associated protein 155; SF3b155; SAP 155; SF3B1; SAP155. |
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |