Overview |
bsm-54153R |
PDX1 (34A1) Monoclonal Antibody |
WB, IHC-P, IF(IHC-P), IF(ICC) |
Human |
Specifications |
Unconjugated |
Rabbit |
Synthetic peptide within C-terminal human PDX1 |
Monoclonal |
34A1 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
3651 |
P52945 |
Pancreas/duodenum homeobox protein 1; Glucose-sensitive factor; Insulin promoter factor 1; Insulin upstream factor 1; Islet/duodenum homeobox-1; Somatostatin-transactivating factor 1; PDX-1; GSF; IPF-1; IUF-1; IDX-1; STF-1; IUF1; MODY4; PAGEN1. |
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IF(IHC-P) |
1:50-200 |
IF(ICC) |
1:50-200 |