Overview |
bsm-54133R |
RAPGEF3 (3D1) Monoclonal Antibody |
WB, IHC-P |
Human, Mouse |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein within human Epac1 aa 700-900 |
Monoclonal |
3D1 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Target |
10411 |
O95398 |
Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; EPAC 1; cAMP-GEFI; RAPGEF3; CGEF1; EPAC; EPAC1; bcm910; HSU79275. |
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |