Overview |
bsm-52532R |
DKK1 (1B10) Monoclonal Antibody |
WB, FCM, IHC-P, IF(ICC), IHC |
Human, Rat |
Specifications |
Unconjugated |
Rabbit |
Recombinant Human DKK1 between 250-350 amino acids |
Monoclonal |
1B10 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
22943 |
O94907 |
Dickkopf-related protein 1, SK, Dickkopf-1, Dkk-1, hDkk-1, DKK1 |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Application Dilution |
WB |
1:300-5000 |
FCM |
1:20-100 |
IHC-P |
1:200-400 |
IF(ICC) |
1:50-200 |
IHC |
|