Overview |
bsm-51105M |
SNX6 (5T6) Monoclonal Antibody |
WB |
Human |
Specifications |
Unconjugated |
Mouse |
This SNX6 monoclonal antibody is generated from mouse immunized with SNX6 recombinant protein. |
Monoclonal |
5T6 |
IgG1 |
0.5ug/ul |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
58533 |
Q9UNH7 |
TFAF2; MSTP010; Sorting nexin-6; TRAF4-associated factor 2; SNX6 |
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). |
Application Dilution |
WB |
1:300-5000 |