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ATG4C (7C2) Monoclonal Antibody

Applications

  • WB

Reactivity

  • Mouse
Overview
Catalog # bsm-51084M
Product Name ATG4C (7C2) Monoclonal Antibody
Applications WB
Reactivity Mouse
Specifications
Conjugation Unconjugated
Host Mouse
Source This ATG4C monoclonal antibody is generated from mouse immunized with ATG4C recombinant protein.
Clonality Monoclonal
Clone # 7C2
Isotype IgG1
Concentration 0.5ug/ul
Purification Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 84938
Swiss Prot Q96DT6
Synonyms APG4C; AUTL1; AUTL3; APG4-C; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C; ATG4C
Background Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Application Dilution
WB 1:300-5000