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GSK872

Overview
Catalog # bs-83050c-5-mg
Product Name GSK872
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information GSK872 is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3).1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 µM).2
Description CAS Number: 1346546-69-7

Chemical Name: N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine

Molecular weight: 383.49

Formula: C19H17N3O2S2

Solubility: DMSO (>25 mg/ml)

Physical Properties: Off-white or pale yellow solid

Purity: 98% by HPLC NMR (Conforms)