SR-717
Overview | |
Catalog # | bs-83048c-10-mg |
Product Name | SR-717 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | -20°C |
Target | |
Product Information | Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM). It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s. |
Description | CAS Number: 2375421-09-1 Chemical Name: Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate Molecular weight: 381.27 Formula: C15H8F2N5O3·Li Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms) |