Quizartinib
| Overview | |
| Catalog # | bs-83030c-5-mg |
| Product Name | Quizartinib |
| Specifications | |
| Storage Buffer | Off-white to beige solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells).1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 µM) via antagonism of drug efflux function.5,6 |
| Description | CAS Number: 950769-58-1 Chemical Name: 1-(5-(t-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea Molecular weight: 560.67 Formula: C29H32N6O4S Solubility: DMSO (>25 mg/ml) Physical Properties: Off-whtie solid Purity: 98% by HPLC |
Powered by Bioz