JNK-IN-8
| Overview | |
| Catalog # | bs-83016c-5-mg |
| Product Name | JNK-IN-8 |
| Specifications | |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | JNK-IN-8 is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK blockade with JNK-IN-8 overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer.2 Improves ARDS-induced cognitive impairment by inhibition of JNK/NF-kB-mediated NLRP3 inflammasome activation.3 |
| Description | CAS Number: 1410880-22-6 Chemical Name: 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Molecular weight: 507.6 Formula: C29H29N7O2 Solubility: DMSO (45 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by HPLC NMR (Conforms) |
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