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SNS-314 mesylate

Overview
Catalog # bs-83015c-5-mg
Product Name SNS-314 mesylate
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information SNS-314 is a potent and selective pan-Aurora kinase inhibitor (IC50’s: Aurora A = 9 nM, Aurora B = 31 nM, Aurora C = 3 nM.1,2 It was able to inhibit proliferation in a wide panel of human cancer cell lines including colon (HCT116), breast (MDA-MB-231), prostate (PC-3), lung (H1299, Calu-6), ovarian (A2780), melanoma (A375) and liver (SMMC-7721, HepG2, LM6).1-4
Description CAS Number: 1146618-41-8

Chemical Name: 1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylate

Molecular weight: 527.04

Formula: C18H15ClN6OS2·CH3SO3H

Solubility: DMSO (>25 mg/ml)

Physical Properties: Off-white solid

Purity: 98% by HPLC NMR (conforms)