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AZ3146

Overview
Catalog # bs-83014c-5-mg
Product Name AZ3146
Specifications
Storage Buffer Yellow/brown solid
Storage Condition -20°C
Target
Product Information AZ3146 is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
Description CAS Number: 1124329-14-1

Chemical Name: 9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-one

Molecular weight: 452.56

Formula: C24H32N6O3S2

Solubility: DMSO (10 mg/ml) Eathnaol (>25 mg/ml)

Physical Properties: Off-white solid

Purity: 98% by HPLC NMR (conforms)