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GSK583

Overview
Catalog # bs-83008c-10-mg
Product Name GSK583
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2
Description CAS Number: 1346547-00-9

Chemical Name: 6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine

Molecular weight: 398.45

Formula: C20H19FN4O2S

Solubility: DMSO (>25 mg/ml)

Physical Properties: Pale yellow solid

Purity: 98% by HPLC NMR (Conforms)